| 產(chǎn)品編號 | bsm-61576R |
| 英文名稱 | RASSF1A Recombinant Rabbit mAb |
| 中文名稱 | Ras相關(guān)區(qū)域家族1A重組兔單抗 |
| 別 名 | NORE2A |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號 | |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | IHC-P=1:50-200,IHC-F=1:50-200,IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 39 kDa |
| 檢測分子量 | 39 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human RASSF1: 300-344/344 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. SWISS: Q9NS23 Gene ID: 11186 RASSF1A是一個腫瘤抑制基因，RASSF1A蛋白的表達(dá)能顯著抑制腫瘤細(xì)胞的生長和轉(zhuǎn)移， 作為一種候選腫瘤抑制基因參與腫瘤的發(fā)生發(fā)展 ,該基因的失活與其啟動子區(qū)甲基化有關(guān)。 該蛋白在惡性腫瘤的發(fā)生發(fā)展中發(fā)揮重要作用。 |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded Human Pancreas; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with RASSF1A Monoclonal Antibody, Unconjugated (bsm-61576R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with RASSF1A Monoclonal Antibody, Unconjugated (bsm-61576R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with RASSF1A Monoclonal Antibody, Unconjugated (bsm-61576R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Lung Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with RASSF1A Monoclonal Antibody, Unconjugated (bsm-61576R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
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