| 產(chǎn)品編號(hào) | bsm-61774R |
| 英文名稱 | Presenilin 1 Recombinant Rabbit mAb |
| 中文名稱 | 早老素蛋白1重組兔單抗 |
| 別 名 | AD3; Ad3h; FAD; Protein S182; PS1-CTF12; PSEN1; PSNL1; S182. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | 5D12 |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000,IHC-P=1:50-200,IHC-F=1:50-200,IF=1:50-200,Flow-Cyt=1:20-1:100
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 53 kDa |
| 檢測分子量 | 28 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human Presenilin 1: 25-78/467 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Requires the presence of the other members of the gamma-secretase complex for protease activity.Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. SWISS: P49768 Gene ID: 5663 此抗體識(shí)別分子量為45-50 kDa早老素蛋白-1。PS-1主要在神經(jīng)細(xì)胞中表達(dá)，該蛋白集中于體細(xì)胞和樹突狀細(xì)胞中。相反，再早發(fā)家族AD（FAD）中和散發(fā)AD病人中，PS1免疫反應(yīng)出現(xiàn)在老年斑和神經(jīng)纖維纏結(jié)的神經(jīng)炎中，樹突狀細(xì)胞中表達(dá)。 |
| 產(chǎn)品圖片 |
Western blot analysis of Jurkat cell lysate. Using Presenilin 1 (bsm-61774R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
Paraformaldehyde-fixed, paraffin embedded Human Glioma; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Presenilin 1 Monoclonal Antibody, Unconjugated(bsm-61774R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Presenilin 1 Monoclonal Antibody, Unconjugated(bsm-61774R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Rat Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Presenilin 1 Monoclonal Antibody, Unconjugated(bsm-61774R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Mouse Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Presenilin 1 Monoclonal Antibody, Unconjugated(bsm-61774R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
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