| 產(chǎn)品編號 | bsm-2022M |
| 英文名稱 | HBeAg Mouse mAb |
| 中文名稱 | 人乙型肝炎e抗原單克?。ò唬┛贵w |
| 別 名 | External core antigen; Precore protein; p25; C; HBEAG_HBVD3; |
 |
Specific References (1) | bsm-2022M has been referenced in 1 publications.
[IF=4.996] Garg, Garima. et al. Presence of entry receptors and viral markers suggest a low level of placental replication of hepatitis B virus in a proportion of pregnant women infected with chronic hepatitis B. SCI REP-UK. 2022 Oct;12(1):1-11 IHC ; Human.
|
| 研究領(lǐng)域 | 免疫學(xué) 細(xì)菌及病毒 |
| 抗體來源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號 | 2E9 |
| 交叉反應(yīng) | HBV |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 18 kDa |
| 檢測分子量 | |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | HBeAg full length protein |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein G |
| 緩 沖 液 | 0.01M PBS (pH7.4) with 0.02% Proclin300. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Hepatitis B e-antigen (HBeAg) is a viral protein associated with HBV infections. Unlike the surface antigen, the e-antigen is found in the blood only when there are viruses also present. When the virus goes into “hiding,” the e-antigen will no longer be present in the blood. HBeAg is often used as a marker of ability to spread the virus to other people (infectivity). Measurement of e-antigen may also be used to monitor the effectiveness of HBV treatment; successful treatment will usually eliminate HBeAg from the blood and lead to development of antibodies against e-antigen (anti-HBe). There are some types (strains) of HBV that do not make e-antigen; these are especially common in the Middle East and Asia. In areas where these strains of HBV are common, testing for HBeAg is not very useful. Function: May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells. This immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections. Subunit: Homodimerizes. Subcellular Location: Secreted. Host nucleus. Post-translational modifications: Phosphorylated. Cleaved by host furin. Similarity: Belongs to the orthohepadnavirus precore antigen family. Database links: SwissProt: Q89714 Hepatitis B virus |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Recombinant HBcAg protein, Tag free
Lane 2: Recombinant hepatitis B virus e virus like particle protein, His
Primary: Anti-HBeAg (bsm-2022M) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 18 kDa
Observed band size: 25 kDa
|
