| 產(chǎn)品編號(hào) | bs-6444R |
| 英文名稱 | CDH11/OB Cadherin Rabbit pAb |
| 中文名稱 | 鈣粘附蛋白-11抗體 |
| 別 名 | Cadherin-11; OB-Cadherin; CDH11, CAD11; CAD11_HUMAN; Cadherin 11; Cadherin 11 type 2; Cadherin 11 type 2 OB cadherin(osteoblast); Cadherin-11; Cdh11; CDHOB; OB; OB-cadherin; OBcadherin; OSF-4; OSF4; Osteoblast cadherin. |
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Specific References (1) | bs-6444R has been referenced in 1 publications.
[IF=2.311] Wang Q et al. Clinical and prognostic association of oncogene cadherin 11 in gastric cancer. Oncol Lett
. 2020 Jun;19(6):4011-4023. IHC ; human.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat,Rabbit,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 90 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CDH11/OB-Cadherin: 301-300/796 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The cadherins are a family of Ca++-dependent adhesion molecules that influence cell-cell binding and are critical to the maintenance of tissue structure and morphogenesis. OB-cadherin (osteoblast-cadherin, cadherin-11, OSF-4) has two forms, OB-cadherin-1 and OB-cadherin-2. OB-cadherin-2 has a truncated cytoplasmic domain, missing amino acids 694-796. Both OB-cadherins are expressed in osteoblastic cell lines with low expression seen in lungs, testis and brain. Function: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Subunit: Interacts with PCDH8 (By similarity). Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts. DISEASE: Note=A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation. Similarity: Contains 5 cadherin domains. SWISS: P55287 Gene ID: 1009 Database links: Entrez Gene: 1009 Human Entrez Gene: 12552 Mouse Omim: 600023 Human SwissProt: P55287 Human SwissProt: P55288 Mouse Unigene: 116471 Human Unigene: 1571 Mouse Unigene: 8900 Rat |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Mouse Ovary tissue lysates
Lane 2: Human MDA-MB-231 cell lysates
Primary: Anti-CDH11/OB Cadherin (bs-6444R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 90 kDa
Observed band size: 120 kDa
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