| 產(chǎn)品編號 | bs-11446R |
| 英文名稱 | ARNTL2 Rabbit pAb |
| 中文名稱 | 芳香烴受體核轉(zhuǎn)錄蛋白樣2抗體 |
| 別 名 | ARNT L2; ARNTL 2; ARNTL2; ARNTL2 protein; Aryl hydrocarbon receptor nuclear translocator like 2; Aryl hydrocarbon receptor nuclear translocator like protein 2; Aryl hydrocarbon receptor nuclear translocator-like 2; Basic helix loop helix PAS protein MOP9; Basic-helix-loop-helix-PAS protein MOP9; bHLHe6; BMA L2; BMAL 2; BMAL2; Brain and muscle ARNT like 2; Brain and muscle ARNT-like 2; CLIF; CYCLE like factor; CYCLE-like factor; Member of PAS protein 9; MGC124257; MGC149671; MGC149672; MGC158186; MOP 9; MOP9; PASD 9; PASD9; Transcription factor BMAL 2; Transcription factor BMAL2; wu:fj90c09; BMAL2_HUMAN. |
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Specific References (1) | bs-11446R has been referenced in 1 publications.
[IF=7.561] Xiao M. et al. A DNA-Methylation-Driven Genes Based Prognostic Signature Reveals Immune Microenvironment in Pancreatic Cancer.. Front Immunol. 2022 Feb;13:803962-803962 IHC ; Human.
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| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 71 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ARNTL2: 381-480/636 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
BMAL2 is a 636 amino acid protein that localizes to the nucleus and contains one bHLH (basic helix-loop-helix) domain, one PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains. Expressed at high levels in placenta and brain and at lower levels in liver, thymus, heart, lung and kidney, BMAL2 functions as a component of the circadian core oscillator, which includes a variety of proteins that work in tandem to activate the transcription of target genes. More specifically, BMAL2, when functioning as a component of the core oscillator, binds to the E-box element (3'-CACGTG-5') of target DNA, thus inducing transcription. Multiple isoforms of BMAL2 exist due to alternative splicing events. Function: ARNTL2 (aryl hydrocarbon receptor nuclear translocator-like 2) is a basic Helix-Loop-Helix-Per-Arnt-Sim (bHLH-PAS) transcription factor. ARNTL2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription. Also, in umbilical vein endothelial cells, ARNTL2 activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1. It may participate in circadian clock regulation Subunit: Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with CLOCK to form the ARNTL2-CLOCK transactivator. Can form heterodimers or homodimers which interact directly with CLOCK to form the transcription activator. Also interacts with NPAS2 and HIF1A. Subcellular Location: Nuclear Tissue Specificity: Expressed in fetal brain. Highly expressed in brain and placenta. Lower levels in heart, liver, thymus, kidney and lung. Located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN). Also detected in endothelial cells of the heart, lung and kidney. In the brain, specifically expressed in the thalamus, hippocampus and amygdala. Similarity: Contains 1 bHLH (basic helix-loop-helix) domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 2 PAS (PER-ARNT-SIM) domains. SWISS: Q8WYA1 Gene ID: 56938 Database links: Entrez Gene: 56938 Human Entrez Gene: 373925 Chicken SwissProt: Q8QGQ7 Chicken SwissProt: Q8WYA1 Human Unigene: 434269 Human |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Testis (Mouse) Lysate at 40 ug
Lane 2: Testis (Rat) Lysate at 40 ug
Primary: Anti-ARNTL2 (bs-11446R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 71/63 kD
Observed band size: 65 kD
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