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GIYD2 Rabbit pAb (bs-13361R)  
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產(chǎn)品編號 bs-13361R
英文名稱 GIYD2 Rabbit pAb
中文名稱 DNA修復(fù)蛋白GIYD2抗體
別    名 FLJ23439; GIY YIG domain containing 2; GIYD 2; MGC2532; MGC5178; SLX1_HUMAN.  
研究領(lǐng)域 細胞生物  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Human (predicted: Mouse,Rat,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 31 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GIYD2: 21-120/275 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene.

Function:
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.

Subunit:
Forms a heterodimer with SLX4.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the SLX1 family.
Contains 1 GIY-YIG domain.
Contains 1 SLX1-type zinc finger.

SWISS:
Q9BQ83

Gene ID:
79008

Database links:

Entrez Gene: 79008 Human

SwissProt: Q9BQ83 Human



產(chǎn)品圖片
Sample: A431(Human) Cell Lysate at 30 ug Primary: Anti- GIYD2 (bs-13361R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 31 kD Observed band size: 31 kD
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