| 產(chǎn)品編號 | bs-16792R |
| 英文名稱 | KMT2C Rabbit pAb |
| 中文名稱 | 組蛋白賴氨酸N-甲基轉(zhuǎn)移酶2C抗體 |
| 別 名 | Histone-lysine N-methyltransferase MLL3; Homologous to ALR protein; KMT2C; Lysine N-methyltransferase 2C; MLL3; KMT2C_HUMAN; Myeloid/lymphoid or mixed-lineage leukemia protein 3; Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog. |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Pig) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 541 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KMT2C: 4701-4800/4911 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008] Function: Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/MLL3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. Subcellular Location: Nucleus. Tissue Specificity: Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver. Similarity: Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. Contains 1 A.T hook DNA-binding domain. Contains 1 DHHC-type zinc finger. Contains 6 PHD-type zinc fingers. Contains 1 post-SET domain. Contains 1 RING-type zinc finger. Contains 1 SET domain. SWISS: Q8NEZ4 Gene ID: 58508 Database links: Entrez Gene: 58508 Human Omim: 606833 Human SwissProt: Q8NEZ4 Human Unigene: 647120 Human |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (mouse testis tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (KMT2C) Polyclonal Antibody, Unconjugated (bs-16792R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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