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Meningioma 1/MN1 Rabbit pAb (bs-17691R)  
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產(chǎn)品編號(hào) bs-17691R
英文名稱 Meningioma 1/MN1 Rabbit pAb
中文名稱 腦膜瘤蛋白1抗體
別    名 AA003644; AA009236; dJ353E16.2; Meningioma(disrupted in balanced translocation) 1; Meningioma(translocation balanced); meningioma chromosome region 1; MGCR; MGCR1; MGCR1-PEN; MN1; MN1_HUMAN; Probable tumor suppressor protein MN1; RGD1565571.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Mouse (predicted: Human,Rat,Pig,Sheep,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 136 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Meningioma 1/MN1: 1201-1320/1320 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008]

Function:
May play a role in tumor suppression.

Tissue Specificity:
Ubiquitously expressed. Highest levels in skeletal muscle.

DISEASE:
Note=A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with TEL. Note=Defects in MN1 involved in the development of meningiomas, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are believed to be the most common primary tumors of the central nervous system in man.

SWISS:
Q10571

Gene ID:
4330

Database links:

Entrez Gene: 4330 Human

Entrez Gene: 433938 Mouse

Entrez Gene: 498194 Rat

Omim: 156100 Human

SwissProt: Q10571 Human

Unigene: 268515 Human



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Meningioma 1) Polyclonal Antibody, Unconjugated (bs-17691R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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