| 產(chǎn)品編號(hào) | D62109 |
| 英文名稱 | GSK484 hydrochloride |
| 中文名稱 | GSK484鹽酸鹽 |
| 別 名 | GTPL8577; AOB6992 |
| 克 隆 號(hào) | |
| CAS | 1652591-81-5 |
| 理論分子量 | 510.03 kDa |
| 檢測(cè)分子量 | |
| 保存條件 | -20℃ |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
GSK484 hydrochloride (GTPL8577) is a reversible peptidyl-arginine deiminase 4 (PAD4) inhibitor. It binds to PAD4 with high affinity, with IC50 of 250 and 50 nM in the presence and absence of 2 mM calcium, respectively. GSK484 promotes the radiosensitivity of colorectal cancer (CRC) and inhibits NET formation in vitro and in vivo. |
