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Mouse eIF3B Ready-To-Use IHC Kit (IHC0502M)  
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產(chǎn)品編號 IHC0502M
英文名稱 Mouse eIF3B Ready-To-Use IHC Kit
中文名稱 小鼠eIF3B蛋白即用型免疫組化試劑盒
別    名 AL033316; AL033334; AL033369; AW208965; D5Wsu45e; EIF3-ETA; EIF3-P110; EIF3-P116; EIF3B; EIF3S9; PRT1  
適用樣品基質(zhì) FFPE tissue
保存條件 Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt.
產(chǎn)品介紹 RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:9388245, PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:9388245, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

SWISS:
P55884

Gene ID:
8662

產(chǎn)品圖片
Immunohistochemical analysis of paraffin embedded Mouse colon tissue slide using IHC0502M (Mouse eIF3B Kit).
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