| 產(chǎn)品編號(hào) | IHC0685H |
| 英文名稱 | Human P63 Ready-To-Use IHC Kit |
| 中文名稱 | 人腫瘤抑制基因p63即用型免疫組化試劑盒 |
| 別 名 | AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; P63; P73H; P73L; RHS; SHFM4; TP53CP; TP53L; TP63; TP73L |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
TP63 (tumor protein 63) acts as a sequence-specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform-specific activity. Isoform 2 activates RIPK4 transcription. TP63 may be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. It is involved in Notch signaling by inducing JAG1 and JAG2. TP63 plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. TP63 is required for limb formation from the apical ectodermal ridge. It also activates transcription of the p21 promoter. Mutations affecting the gene can result in Acro-dermato-ungual-lacrimal-tooth syndrome, ankyloblepharon-ectodermal defects-cleft lip/palate, ectrodactyly ectodermal dysplasia, split-hand/foot malformation 4, limb-mammary syndrome, ectodermal dysplasia - Rapp-Hodgkin type, and orofacial cleft 8. SWISS: Q9H3D4 Gene ID: 8626 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded Human breast cancer tissue slide using IHC0685H (Human P63 Kit).
Immunohistochemical analysis of paraffin embedded Human mammary gland tissue slide using IHC0685H (Human P63 Kit).
Immunohistochemical analysis of paraffin embedded Human prostate tissue slide using IHC0685H (Human P63 Kit).
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