| 產(chǎn)品編號 | bs-14069R-BF350 |
| 英文名稱 | Rabbit Anti-CRSP8/BF350 Conjugated antibody |
| 中文名稱 | BF350標(biāo)記的轉(zhuǎn)錄激活蛋白CRSP8抗體 |
| 別 名 | Cofactor required for Sp1 transcriptional activation subunit 8 (34kD); Cofactor required for Sp1 transcriptional activation subunit 8 34kDa; Cofactor required for Sp1 transcriptional activation subunit 8; CRAP 34; CRAP34; CRSP 34; CRSP 8; CRSP complex subunit 8; CRSP34; MED 27; Med27; MED27_HUMAN; Mediator complex subunit 27; Mediator of RNA polymerase II transcription subunit 27; MGC11274; P37 TRAP/SMCC/PC2 subunit; Transcriptional coactivator CRSP34; TRAP 37; TRAP37. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 35kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CRSP8 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011] Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Subcellular Location: Nucleus. Similarity: Belongs to the Mediator complex subunit 27 family. Database links: Entrez Gene: 9442 Human Entrez Gene: 68975 Mouse Omim: 605044 Human SwissProt: Q6P2C8 Human SwissProt: Q9DB40 Mouse Unigene: 374262 Human Unigene: 330109 Mouse Unigene: 105472 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
