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Rabbit Anti-TRF4-2/BF594 Conjugated antibody (bs-16715R-BF594)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-16715R-BF594
英文名稱 Rabbit Anti-TRF4-2/BF594 Conjugated antibody
中文名稱 BF594標記的拓撲異構酶相關功能蛋白4-2抗體
別    名 PAP-associated domain-containing protein 5; Terminal uridylyltransferase 3; Topoisomerase related function protein 4-2; TRF4-2; PAPD5_HUMAN; TUTase 3.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 轉錄調節(jié)因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 63kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRF4-2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion

Function:
Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion.

Subunit:
Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase

Subcellular Location:
Nuclear

Similarity:
Belongs to the DNA polymerase type-B-like family.
Contains 1 PAP-associated domain.

Database links:

Entrez Gene: 64282 Human

Omim: 605540 Human

SwissProt: Q8NDF8 Human

Unigene: 514342 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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