| 產(chǎn)品編號(hào) | bs-18710R-PE-Cy3 |
| 英文名稱 | Rabbit Anti-MBTD1/PE-Cy3 Conjugated antibody |
| 中文名稱 | PE-Cy3標(biāo)記的MBTD1蛋白抗體 |
| 別 名 | AA408199; AI194990; FLJ20055; FLJ42067; Hemp; mbt domain containing 1; MBT domain-containing protein 1; mbtd1; MBTD1_HUMAN; MGC126785; RP23-440P13.2; SA49P01. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 71kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MBTD1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The transcriptional repressing Polycomb-group (PcG) family is a part of a cellular memory system responsible for the stable inheritance of gene activity. PcG proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. MBTD1 (malignant brain tumor domain containing 1) is a 628 amino acid nuclear protein that belongs to the PcG family of proteins. Existing as a monomer, MBTD1 undergoes alternative splicing events to produce three isoforms. MBTD1 contains one FCS-type zinc finger and four MBT repeats, and is encoded by a gene that maps to human chromosome 17q21.33. Chromosome 17 comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Function: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. Subcellular Location: Nucleus. Similarity: Contains 1 FCS-type zinc finger. Contains 4 MBT repeats. Database links: Entrez Gene: 54799 Human Entrez Gene: 103537 Mouse SwissProt: Q05BQ5 Human SwissProt: Q6P5G3 Mouse Unigene: 656803 Human Unigene: 210334 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
